MM 07 ( —— )

产品货号. M30642 CAS No. 1876450-21-3

Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
100MG	获取报价	有现货
200MG	获取报价	有现货
500MG	获取报价	有现货

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生物学信息

产品名称

MM 07
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.
产品描述

Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic and vasodilatory effects in vivo and improves cardiac structure and function in a model of pulmonary arterial hypertension.
体外实验

MM 07 competes with nanomolar affinities for binding of [Glp65,Nle75,Tyr77] [125I]apelin-13 to human apelin receptors in CHO-K1 cells (KD, 300 nM) and human heart (KD, 172 nM, n=3).
体内实验

MM 07 causes a dose-dependent increase in cardiac output, and although there is a decrease in vascular resistance, this is without corresponding effects on BP. Administration of SNAP produces a profound fall in BP in both [Pyr1]apelin-13 and MM 07-treated groups; however, although cardiac output is significantly increased in response to SNAP in the MM 07 group, it is significantly reduced in the [Pyr1]apelin-13 group. Neither peptide causes a significant change in heart rate, respiratory rate, or temperature. Both [Pyr1]apelin 13 and MM 07 increases peak velocity above basal levels.
同义词

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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化学信息

CAS Number

1876450-21-3
分子量

1539.89
分子式

C67H106N22O14S3
纯度

>98% (HPLC)
溶解度

water:2 mg/mL
SMILES

O=C(N(CCC1)[C@@H]1C(N[C@H](C(O)=O)CC2=CC=CC=C2)=O)[C@H](CCSC)NC([C@H](CCC3)N3C(CNC([C@H](CCCCN)NC([C@@H](NC([C@H](CSSC[C@@H](C(N[C@@]4([H])CCCNC(N)=N)=O)N)NC([C@](NC([C@@H](NC([C@@](CCC5)([H])N5C4=O)=O)CCCNC(N)=N)=O)([H])CC(C)C)=O)=O)CC6=CN=CN6)=O)=O)=O)=O
化学全称

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运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Brame et al (2015) Design, characterization, and first-in-human study of the vascular actions of a novel biased apelin receptor agonist. Hypertension 65 834 PMID:

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